The “One Big Beautiful Bill Act” will be one big disaster for Massachusetts’ health care system and those who rely on it.

How big? Approximately 326,000 Massachusetts residents — almost 5 percent of the entire state population — are expected to lose insurance coverage under the bill, according to the Congressional Budget Office. Massachusetts will lose an estimated $1.97 billion in Medicaid funding in 2029 (once provisions are fully phased in), according to The Commonwealth Fund. State officials said total cuts to Massachusetts’ federal health care funding could be as high as $3.5 billion annually. And the ripple effects of those cuts could raise costs for businesses and consumers, too.

Massachusetts can’t replace all those lost federal dollars, but it can limit the damage to residents by convening representatives of all segments of the local health care industry and prodding them to work together on a response.

One major impact of the bill they’ll need to contend with is the new administrative barriers, like work requirements, it created for enrollees in MassHealth, the state Medicaid program for low-income residents.

While the vast majority of Medicaid recipients are already working or would qualify for an exemption, states with work requirements typically see people lose coverage because they don’t provide the necessary paperwork.

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